Indication
Kaposi’s sarcoma, Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, nonlymphocytic leukemia, and glioblastoma multiforme. bone marrow or blood stem cell transplant.
Contra Indication
Hypersensitivity. Severe liver dysfunction. Pregnancy and lactation.
Caution
Renal disease, infections, avoid contact with the skin, mucosa and eye.
Side Effect
Low blood pressure, hair loss, pain and or burning at the IV site, constipation or diarrhea, metallic food taste, Bone marrow suppression, leading to: decreased white blood cell counts, low red blood cell counts, low platelet counts, nausea and vomiting, allergic-type reactions, rash, fever, often occurring shortly after IV administration and not due to infection, mouth sores, Acute myeloid leukemia, when given with warfarin, it may cause bleeding.