Ipca Laboratory P. Ltd.
Blood and Blood formation
Blood is a constantly circulating fluid providing the body with nutrition, oxygen, and waste removal. Blood is mostly liquid, with numerous cells and proteins suspended in it, making blood ""thicker"" than pure water. The average person has about 5 liters (more than a gallon) of blood.
A liquid called plasma makes up about half of the content of blood. Plasma contains proteins that help blood to clot, transport substances through the blood, and perform other functions. Blood plasma also contains glucose and other dissolved nutrients.
About half of blood volume is composed of blood cells:
• Red blood cells, which carry oxygen to the tissues.
• White blood cells, which fight infections.
• Platelets, smaller cells that help blood to clot.
Blood is conducted through blood vessels (arteries and veins). Blood is prevented from clotting in the blood vessels by their smoothness, and the finely tuned balance of clotting factors."
Erythropoietin
Erythropoietin is an essential hormone for red cell production. Without it, definitive erythropoiesis, the process of red cell production, does not take place. Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, pro-erythroblast and basophilic erythroblast subsets in the differentiation. Erythropoietin has its primary effect on red blood cell progenitors and precursors (which are found in the bone marrow in humans) by promoting their survival through protecting these cells from apoptosis.
API For Erythropoietin
Alcon Laboratories Pvt. Ltd. (Novartis India)