Indication
Bladder carcinoma, Metastatic germ cell cancers (seminoma and teratoma), Metastatic ovarian carcinoma, Metastatic testicular cancer, Non-small cell lung carcinoma, Small cell lung cancer, Squamous cell carcinoma.
Contra Indication
Hypersensitivity. Renal impairment. Pregnancy, lactation and children. The risk of hearing loss is increased.
Caution
Patients with renal or hepatic disorder, myelosuppression. Monitor renal, neurological and auditory function. Perform blood counts regularly. Maintain adequate hydration before and 24 hr after admin to minimise nephrotoxicity.
Side Effect
Hypersensitivity reactions, Ototoxicity, Neuropathy, Reduction in creatinine clearance, Elevation in serum creatinine, Vascular toxicity. Myelosuppression, Renal damage, Anaphylactic reactions, Tinnitus, Anorexia, Nausea, Vomiting, Azotemia.