Indication
Chronic myeloid leukaemia, Granulocytic leukemia, Polycythemia vera, Myelofibrosis, Thrombocythaemia.
Contra Indication
Pregnancy and lactation. Hypersensitivity.
Caution
Prior treatment with other myelosuppressive drugs, patients predisposed to seizures. May cause secondary malignancies (tumors, acute leukaemias, ovarian failure). Previous irradiation/therapy. Monitor blood counts carefully during therapy. Discontinue if lung toxicity develops.
Side Effect
GI symptoms, anorexia, wt loss, weakness, hyperpigmentation, amenorrhoea, cataracts, cough or hoarseness, impaired fertility and gonadal function, dry skin, liver damage, gynaecomastia.