Glaxo Smithkline Pharmaceuticals Ltd.
"The skin is the largest organ of the body, with a total area of about 20 square feet. The skin protects us from microbes and the elements, helps regulate body temperature, and permits the sensations of touch, heat, and cold.
Skin has three layers: The epidermis, the outermost layer of skin, provides a waterproof barrier and creates our skin tone.
The dermis, beneath the epidermis, contains tough connective tissue, hair follicles, and sweat glands.
The deeper subcutaneous tissue (hypodermis) is made of fat and connective tissue.
The skin’s color is created by special cells called melanocytes, which produce the pigment melanin. Melanocytes are located in the epidermis."
A paresthesia is an abnormal sensation of tingling, numbness, or burning. Paresthesias are usually felt in the hands, feet, arms, or legs, but can be felt anywhere. The sensation is usually unpleasant. Most people have experienced paresthesia, in the form of the pins-and-needles sensation that occurs when an arm or leg briefly “falls asleep.” The sensation is caused by sustained pressure placed on a nerve. This kind of paresthesia is temporary and reversible.