Pre-existing coronary heart disease, atherosclerosis related disorders e.g. hyperlipidaemia. diabetes, obesity, hypertension, lipid rich diet.
Anticoagulant treatrnent (bleeding time increased), hepatic impairment, pregnancy, Children.
Haemorrhagic disorders or those receiving anticoagulants or other drugs that have antithrombotic activity, asthmatic patients sensitive to aspirin. Monitor hepatic function in patients with hepatic impairment, especially if receiving high doses.
GI disturbances, including nausea, eructation, vomiting, abdominal distension, diarrhoea and constipation. Acne and eczema. Moderate increases in hepatic transaminases in patients with hypertriglyceridaemia.