Nitrofurantoin
Indication
Muscle relaxation (long duration) for surgery and intubation, Prophylaxis of UTI, Uncomplicated UTIs, Urinary tract infection.
Contra Indication
Hypersensitivity. Impaired renal function. Pregnancy and neonates. Severe oliguria or anuria. G6PD deficiency.
Caution
Elderly. Monitor hepatic and pulmonary function during prolonged therapy. Pre-existing pulmonary, hepatic, neurological, or allergic disorders, predisposition to peripheral neuropathy e.g. renal impairment, anaemia, DM, electrolyte imbalance, debility, vitamin B deficiency. Withdraw if signs of peripheral neuropathy occur. Lactation.
Side Effect
Nausea, vomiting, anorexia, abdominal pain, diarrhoea, headache, vertigo, rash, urticaria, lupus-like syndrome, haemolytic anaemia. Peripheral polyneuropathy, hepatotoxicity, anaphylaxis. interstitial pneumonitis.
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