Blood

"Blood is a constantly circulating fluid providing the body with nutrition, oxygen, and waste removal. Blood is mostly liquid, with numerous cells and proteins suspended in it, making blood ""thicker"" than pure water. The average person has about 5 liters (more than a gallon) of blood.
A liquid called plasma makes up about half of the content of blood. Plasma contains proteins that help blood to clot, transport substances through the blood, and perform other functions. Blood plasma also contains glucose and other dissolved nutrients.
About half of blood volume is composed of blood cells:
• Red blood cells, which carry oxygen to the tissues.
• White blood cells, which fight infections.
• Platelets, smaller cells that help blood to clot.
Blood is conducted through blood vessels (arteries and veins). Blood is prevented from clotting in the blood vessels by their smoothness, and the finely tuned balance of clotting factors."

Thromboangiitis obliterans

Thromboangiitis obliterans is a rare disease in which blood vessels of the hands and feet become blocked. There is a recurrent acute and chronic inflammation and thrombosis of arteries and veins of the hands and feet. The main symptom is pain in the affected areas, at rest and while walking (claudication). The impaired circulation increases sensitivity to cold. Peripheral pulses are diminished or absent. There are color changes in extremity. The colour may range from cyanotic blue to reddish blue. Skin becomes thin and shiny. Hair growth is reduced. Ulcerations and gangrene in the extremities are common complications, often resulting in the need for amputation of the involved extremity.